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Endothelial Nitric Oxide Synthase - A Target for Stroke Protection by Statins

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Endothelium-derived nitric oxide (eNO) is a central regulator of vascular function and blood flow. eNO is a potent vasodilator, inhibits platelet aggregation and prevents monocytes adhesion. In addition, NO availability is an important determinant of the functional capacity of endothelial progenitor cells and neovascularization. Consequently, eNO plays a central protective role during the pathogenesis of ischaemic stroke. Experimental and clinical studies have demonstrated that statins increase the bio- availability of endothelial NO indirectly via cholesterol-lowering as well as through direct cholesterol-independent mechanisms. On the basis of animal studies and clinical trials, statins have emerged as a potential novel strategy to protect from ischaemic strokes. These data raise the questions whether patients with acute cerebral ischaemia may benefit from intravenous treatment with a statin and, whether these patients are at risk when their ongoing statin treatment is withdrawn.

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Keywords: Statins; endothelium; nitric oxide; stroke

Document Type: Research Article

Publication date: 2008-06-01

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  • Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in the medicinal chemistry and rational drug design for the discovery of new Immunology, Endocrine & Metabolic Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Immunology, Endocrine & Metabolic medicinal chemistry.

    Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Immunology, Endocrine & Metabolic drug discovery.
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