Adipobiology of Diabetes Mellitus
Authors: Kim, M. J.1; Lee, E. Y.1; Lee, M. Y.1; Chung, C. H.1
Source: Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry (Formerly, Volume 7, Number 2, April 2007 , pp. 123-127(5)
Publisher: Bentham Science Publishers
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Abstract:
Accumulating basic and clinical studies indicate that adipose tissue cells (adipocytes, matrix cells, stromovascular cells and associated macrophages) synthesize and release multiple signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with glucose and lipid metabolism being a key example. This defines a new field of study: adipobiology of type 2 diabetes mellitus. The importance of diabetes-related (diabetogenic) adipokines, with an emphasis on adiponectin, resistin, leptin, angiotensin II, tumor necrosis factor-α , interleukin-6, and visfatin, is reviewed. Competing of pro- and anti-diabetogenic adipokine-mediated signals may pivotally be involved in the adipobiology of diabetes. This paradigm may reveal further new tools for drug development against diabetes and related disorders.Keywords: Adiponectin; angiotensin II; drugs; IL-6; leptin; resistin; TNF-α; visfatin
Document Type: Research article
DOI: 10.2174/187152207780363776
Affiliations: 1: Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University Wonju College of Medicine, 162 Ilsan-Dong, Wonju, Korea 220-701.
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