Authors: Kim, M. J.; Lee, E. Y.; Lee, M. Y.; Chung, C. H.

Source: Immunology Endocrine & Metabolic Agents - Medicinal Chemistry (Formerly Current Medicinal Chemistry - Immunology Endocrine & Metabolic Agents), Volume 7, Number 2, April 2007 , pp. 123-127(5)

Publisher: Bentham Science Publishers

Abstract:

Accumulating basic and clinical studies indicate that adipose tissue cells (adipocytes, matrix cells, stromovascular cells and associated macrophages) synthesize and release multiple signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with glucose and lipid metabolism being a key example. This defines a new field of study: adipobiology of type 2 diabetes mellitus. The importance of diabetes-related (diabetogenic) adipokines, with an emphasis on adiponectin, resistin, leptin, angiotensin II, tumor necrosis factor-α , interleukin-6, and visfatin, is reviewed. Competing of pro- and anti-diabetogenic adipokine-mediated signals may pivotally be involved in the adipobiology of diabetes. This paradigm may reveal further new tools for drug development against diabetes and related disorders.

Keywords: Adiponectin; angiotensin II; drugs; IL-6; leptin; resistin; TNF-α; visfatin

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187152207780363776

Affiliations: 1: Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University Wonju College of Medicine, 162 Ilsan-Dong, Wonju, Korea 220-701.

Publication date: 2007-04-01

More about this publication?

• Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in the medicinal chemistry and rational drug design for the discovery of new Immunology, Endocrine & Metabolic Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Immunology, Endocrine & Metabolic medicinal chemistry.
  
  Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Immunology, Endocrine & Metabolic drug discovery.

Related content

• In this: publication
• By this: publisher
• In this Subject: Chemistry ,  Allergy & Immunology ,  Pharmacology
• By this author: Kim, M. J. ;  Lee, E. Y. ;  Lee, M. Y. ;  Chung, C. H.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers