Authors: Eleftheriadis, Theodoros; Lawson, Brian R.

Source: Inflammation & Allergy - Drug Targets (Formerly ???Current Drug Targets, Volume 8, Number 3, July 2009 , pp. 191-201(11)

Publisher: Bentham Science Publishers

Abstract:

Toll like receptors (TLRs) have been extensively studied since their discovery in 1997, and an increasingly detailed picture is emerging about their role in health and disease. TLRs, the first identified family of pattern recognition receptors, can recognize invaders through the exogenous pathogen-associated molecular patterns (PAMPs) and tissue injury through the endogenous danger-associated molecular patterns (DAMPs). In addition to immunocytes, TLRs are widely distributed in various cell types, including renal cells where they are thought to play a significant role in immune activation to pathogens, as well as the development and course of various kidney pathologies. This review summarizes the present data about the important role TLRs play in kidney diseases focusing on the specific role of PAMPs versus DAMPs and of local versus systemic TLR activation.

Document Type: Research article

DOI: 10.2174/187152809788680985

More about this publication?

• Inflammation & Allergy - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in inflammation and allergy e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in inflammation and allergy. As the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continues to grow, this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

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