Authors: Masuda, Atsuhiro; Yoshida, Masaru; Shiomi, Hideyuki; Morita, Yoshinori; Kutsumi, Hiromu; Inokuchi, Hideto; Mizuno, Shigeto; Nakamura, Akira; Takai, Toshiyuki; Blumberg, Richard S.; Azuma, Takeshi

Source: Inflammation & Allergy - Drug Targets, Volume 8, Number 1, March 2009 , pp. 80-86(7)

Publisher: Bentham Science Publishers

Abstract:

It has been forty years since the discovery of Fc Receptors and their function. Fc Receptors include the IgG receptors (FcγR), high-affinity IgE receptor (FcηRI), IgA and IgA/IgM receptors, and neonatal Fc receptor for IgG (FcRn). In particular, the FcγRs have been well known to play an important role in many biologic processes including those associated with the response to infection and cancer as well as in the pathogenesis of immune-mediated diseases. Both positive and negative regulatory function has ascribed to Fc receptors and FcγRs in particular which serve to establish a threshold for immune cell activation. In other cases, Fc receptors such as FcRn possess a novel structure and function by playing a major role in the transport of IgG across polarized epithelial barriers at mucosal surfaces and in the regulation of IgG halflife. These diverse functions highlight the potential effectiveness of targeting Fc receptors for therapeutic purposes. This review summarizes new information available in the therapeutic applications of this biology.

Keywords: Fc receptors; FcRn; IgG; FcγR

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187152809787582525

Publication date: 2009-03-01

More about this publication?

• Inflammation & Allergy - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in inflammation and allergy e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in inflammation and allergy. As the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continues to grow, this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Related content

• In this: publication
• By this: publisher
• In this Subject: Allergy & Immunology ,  Pharmacology
• By this author: Masuda, Atsuhiro ;  Yoshida, Masaru ;  Shiomi, Hideyuki ;  Morita, Yoshinori ;  Kutsumi, Hiromu ;  Inokuchi, Hideto ;  Mizuno, Shigeto ;  Nakamura, Akira ;  Takai, Toshiyuki ;  Blumberg, Richard S. ;  Azuma, Takeshi

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers