Authors: Escribano, Luis; Akin, Cem; Castells, Mariana; Schwartz, Lawrence B.

Source: Inflammation & Allergy - Drug Targets, Volume 5, Number 1, January 2006 , pp. 61-77(17)

Publisher: Bentham Science Publishers

Abstract:

Patients with mastocytosis have symptoms related to the tissue response to the release of mediators from mast cells (MC), local mast cell burden or associated non-mast cell hematological disorders. MC contain an array of biologically active mediators in their granules, which are preformed and stored. MC are also able to produce newly generated membrane-derived lipid mediators and are a source of multifunctional cytokines. Mediator-related symptoms can include pruritus, flushing, syncope, gastric distress, nausea and vomiting, diarrhea, bone pain and neuropsychiatric disturbances; these symptoms are variably controlled by adequate medications.

Management of patients within all categories of mastocytosis includes: a) a careful counseling of patients (parents in pediatric cases) and care providers, b) avoidance of factors triggering acute mediator release, c) treatment of acute and chronic MC-mediator symptoms and, if indicated, d) an attempt for cytoreduction and treatment of organ infiltration by mast cells.

Keywords: Mastocytosis; mast cell-mediator related symptoms; treatment

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187152806775269303

Affiliations: 1: Hospital Ramon y Cajal, Servicio de Hematologia, Carretera de Colmenar Km. 9.1, Madrid 28034, Spain;

Publication date: 2006-01-01

More about this publication?

• Inflammation & Allergy - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in inflammation and allergy e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in inflammation and allergy. As the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continues to grow, this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

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