Frontiers in Medicinal Chemistry

Editorial
pp. iv-iv(1)
Authors: Reitz, Allen B.; Kordik, Cheryl P.; Atta-ur-Rahman; Choudhary, M. I.

Contributors
pp. viii-xiii(6)

Structure and Function of HIV-1 Integrase: An Update
pp. 3-22(20)
Authors: Chiu, Thang K.; Davies, David R.

Anti-HIV Drugs and Resistance: Inhibitors of HIV-1 Reverse Transcriptase and Protease
pp. 23-44(22)
Author: Imamichi, Tomozumi

Drug Development and the Importance of Ethnicity: Lessons from Heart Failure Management and Implications for Hypertension
pp. 45-58(14)
Authors: Sosin, Michael D.; Bhatia, Gurbir S.; Lip, Gregory Y.H.; Davis, Russell C.

Gene Therapy for Cardiovascular Diseases
pp. 59-85(27)
Authors: Gruchala, Marcin; Roy, Himadri; Bhardwaj, Shalini; Yla-Herttuala, Seppo

Design and Discovery of Novel Antihypertensive Drugs Through Conformation and Bioactivity Studies
pp. 87-111(25)
Authors: Mavromoustako, Thomas M.; Zervou, Maria V.; Zoumpoulakis, Panagiotis G.

Novel Antiarrhythmic Compounds with Combined Class IB and Class III Mode of Action
pp. 113-124(12)
Authors: Matyus, Peter; Varga, Ildiko; Rettegi, Tivadar; Simay, Antal; Kovacs, Peter; Karolyhazy, Laszlo; Kocsis, Akos; Vajda, Szilvia; Varro, Andras; Penzes, Istvan; Gy. Papp, Julius

A1 Adenosine Receptor Agonists: Medicinal Chemistry and Therapeutic Potential
pp. 125-151(27)
Authors: Hutchinson, Sally A.; Scammells, Peter J.

Are the Extracellular Pathways a Conduit for the Delivery of Therapeutics to the Brain?
pp. 153-161(9)
Author: Banks, William A.

A Review of Neuroprotective Agents
pp. 163-194(32)
Authors: Brimble, Margaret A.; Levi, Mark S.

Design of Ligands for the Nicotinic Acetylcholine Receptors: The Quest for Selectivity
pp. 195-247(53)
Authors: Bunnelle, William H.; Dart, Michael J.; Schrimpf, Michael

New Trends in the Design of Drugs Against Alzheimer's Disease
pp. 249-284(36)
Authors: Francotte, Pierre; Tullio, Pascal d.; Fraikin, Pierre; Pirotte, Bernard

Development of Melanocortin Receptor Selective Ligands
pp. 285-334(50)
Authors: Irani, Boman G.; Holder, Jerry R.; Todorovic, Aleksandar; Wilczynski, Andrzej M.; Joseph, Christine G.; Wilson, Krista R.; Haskell-Luevano, Carrie

Inhibition of Protein Tyrosine Phosphatase 1B for the Treatment of Diabetes and Obesity
pp. 335-368(34)
Authors: Pei, Zhonghua; Liu, Gang; Lubben, Thomas H.; Szczepankiewicz, Bruce G.

The Impact of Infection on the Incidence of Autoimmune Disease
pp. 369-382(14)
Authors: Thomas, Thomas D.C.; Zaccone, Paola; Dunne, David W.; Cooke, Anne

Transcription Factors in Autoimmune Diseases
pp. 383-397(15)
Authors: Eggert, Martin; Kluter, Andreas; Zettl, Uwe K.; Neeck, Gunther

Small Molecule FLT3 Tyrosine Kinase Inhibitors
pp. 399-416(18)
Authors: Levis, Mark; Small, Donald

Potentiality and Limitations of a Strategy for the Control of Cell Proliferation: The Block of Ca2+ Entry
pp. 417-433(17)
Authors: Munaron, Luca; Antoniotti, Susanna; Pla, Alessandra F.; Lovisolo, Davide

An Expanding Appreciation of the Role Chemokine Receptors Play in Cancer Progression
pp. 435-454(20)
Authors: Howard, O. M. Z.; Galligan, Carole L.

Structural Bioinformatics and its Impact to Biomedical Science and Drug Discovery
pp. 455-502(48)
Author: Chou, Kuo-Chen

Recent Advances in Chemical Genomics
pp. 503-550(48)
Authors: Dorman, Gyorgy; Krajcsi, Peter; Puskas, Laszlo G.; Kovari, Zoltan; Lorincz, Zsolt; Urge, Laszlo; Darvas, Ferenc

Predicting Molecular Interactions In Silico: I. An Updated Guide to Pharmacophore Identification and its Applications to Drug Design
pp. 551-584(34)
Authors: Dror, Oranit; Shulman-Peleg, Alexandra; Nussinov, Ruth; Wolfson, Haim J.

Predicting Molecular Interactions In Silico: II. Protein-Protein and Protein-Drug Docking
pp. 585-613(29)
Authors: Schneidman-Duhovny, Dina; Nussinov, Ruth; Wolfson, Haim J.

In Silico Methods for Predicting Ligand Binding Determinants of Cytochromes P450
pp. 615-652(38)
Authors: de Groot, Marcel J.; Kirton, Stewart B.; Sutcliffe, Michael J.

Trends in Hit-to-Lead: An Update
pp. 653-673(21)
Authors: Deprez, Benoit; Deprez-Poulain, Rebecca

Recent Development and Application of Virtual Screening in Drug Discovery: An Overview
pp. 675-703(29)
Authors: Hou, Tingjun; Xu, Xiaojie

Biology of Heme in Health and Disease
pp. 705-714(10)
Authors: Wijayanti, Nastiti; Immenschuh, Stephan

Subject Index
pp. 715-734(20)