Partition of Solvents and Co-Solvents of Nanotubes: Proteins and Cyclopyranoses

Author: Torrens, Francisco

Source: Frontiers in Drug Design & Discovery, Volume 1, Number 1, January 2005 , pp. 231-266(36)

Publisher: Bentham Science Publishers

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Abstract:

The main contribution to the water-accessible surface area of lysozyme helices is the hydrophobic term, while the hydrophilic part dominates in the sheet, what is related to the 1-octanol-, cyclohexane- and chloroform-water partition coefficients Po-ch-cf of helices, which are greater than those of the sheet are. The analysis of atom-group partial contributions to logPo-ch-cf allows building local maps. The molecular lipophilicity pattern differentiates among helices, sheet and binding site. For a given atom, logP is sensitive to the presence of other atoms. The contributions of C70-a-c atoms to logP are slightly greater than that of d-e are, which correlate with the distances from the nearest pentagon. (10,10) is the favourite single-wall carbon nanotube (SWNT), presenting consistency between a relatively small aqueous solubility and great Po-ch-cf. Efforts to use fullerenes-SWNTs in therapeutic applications are re-evaluated. There is a strong possibility for hydrophobic interactions between proteins and fullerenes-SWNTs in biomilieu, when the latter is used for biomedical applications, unless the molecule is delivered effectively at the intended site of action.

Keywords: single-wall carbon nanotubes (swnt); fullerene; bioactivities; stabilization; supramolecular structures; water-soluble polymers; surfactants; radical scavenging; drug-delivery systems; diastereomers

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1574088054583408

Affiliations: 1: Institut Universitari de Ciencia Molecular, Universitat de Valencia, Dr. Moliner 50, E-46100 Burjassot (València), Spain.

Publication date: 2005-01-01