Authors: Lawless, M. W.; Norris, S.; O'Byrne, K. J.; Gray, S. G.

Source: Endocrine, Metabolic & Immune Disorders - Drug Targets(Formerly Current Dru, Volume 9, Number 1, March 2009 , pp. 84-107(24)

Publisher: Bentham Science Publishers

Abstract:

The `histone code' is a well-established hypothesis describing the idea that specific patterns of post-translational modifications to histones act like a molecular “code” recognised and used by non-histone proteins to regulate specific chromatin functions. One modification which has received significant attention is that of histone acetylation. The enzymes which regulate this modification are described as histone acetyltransferases or HATs, and histone deacetylases or HDACs [1]. Due to their conserved catalytic domain HDACs have been actively targeted as a therapeutic target. The proinflammatory environment is increasingly being recognised as a critical element for both degenerative diseases and cancer. The present review will discuss the current knowledge surrounding the clinical potential & current development of histone deacetylases for the treatment of diseases for which a proinflammatory environment plays important roles, and the molecular mechanisms by which such inhibitors may play important functions in modulating the proinflammatory environment.

Keywords: Breast; pancreas; diabetes; lupus; multiple sclerosis; chaperone; histone deacetylase

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187153009787582441

Publication date: 2009-03-01

More about this publication?

• This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders.

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• In this Subject: Allergy & Immunology ,  Medicine (General) ,  Pharmacology
• By this author: Lawless, M. W. ;  Norris, S. ;  O'Byrne, K. J. ;  Gray, S. G.

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