Authors: Chen, X.; Zheng, C. J.; Han, L. Y.; Xie, B.; Chen, Y. Z.

Source: Endocrine, Metabolic & Immune Disorders - Drug Targets, Volume 7, Number 3, September 2007 , pp. 225-231(7)

Publisher: Bentham Science Publishers

Abstract:

A number of therapeutic targets have been explored for developing drugs in the treatment of endocrine, metabolic and immune disorders. Continuous efforts and increasing interest have been directed at the search of new targets. Data from the therapeutic target database at http://bidd.nus.edu.sg/group/cjttd/ttd.asp, shows that there are 26, 24, and 22 targets of marketed drugs for the treatment of these three classes of diseases, respectively. The number of targets of investigational agents has reached 98, 124, and 72, respectively. An analysis of these targets, particularly those of recently approved drugs and patented investigational agents, provides useful hint about the general trends of target exploration, with current focus on drug discovery and the difficulties encountered in developing drugs against these targets. Multiple profiles of these targets have been analyzed to probe the sequence, structural, physicochemical and systems-related features contributing to the successful exploration of a target against these diseases.

Keywords: Drug; drug design; drug discovery; drug target; disease; pharmacology; pharmacy; therapeutics; therapy; treatment

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187153007781662576

Publication date: 2007-09-01

More about this publication?

• This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders.

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• In this Subject: Allergy & Immunology ,  Medicine (General) ,  Pharmacology
• By this author: Chen, X. ;  Zheng, C. J. ;  Han, L. Y. ;  Xie, B. ;  Chen, Y. Z.

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