Anthracyclines-Contra Cruciform Extrusion in DNA Regulating Sequences

Author: Viglasky, Viktor

Source: Endocrine, Metabolic & Immune Disorders - Drug Targets, Volume 6, Number 3, September 2006 , pp. 295-302(8)

Publisher: Bentham Science Publishers

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Abstract:

Despite the existence of a wealth of structural and theoretical data relating to palindromic sequences in the genome, the mechanism of cruciform formation in the presence of anthracyclines in miscellaneous biological processes is still poorly understood. Generally, DNA intercalators influence the DNA superhelicity, which plays a key role in the cruciform formation in DNA molecules. The potential of DNA intercalating ligands on the stabilization/destabilization of cruciform in DNA is discussed. Here, the indirect impact of anthracyclines to cell developing and surviving is analyzed for the first time. Primarily, the anthracycline modifies the helical properties of DNA and the overall DNA structure, and secondarily alters any cruciform-dependent processes, mainly DNA replication and transcription.

Keywords: DNA structure; Anthracyclines; Supercoiling; self-complementary sequence; cruciform motif

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187153006778250046

Affiliations: 1: Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, P.J. afarik University, Ko ice,Slovakia.

Publication date: 2006-09-01

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This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders.