Author: Soory, Mena

Source: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, Volume 3, Number 3, November 2009 , pp. 214-224(11)

Publisher: Bentham Science Publishers

Abstract:

This review addresses the relevance of the consequences of dyslipidaemia amongst patients with diabetes mellitus, cardiovascular and periodontal diseases. Significant presentation of periodontal disease amongst poorly controlled diabetics with cardiovascular complications is an important area for a coordinated therapeutic approach. The pro-inflammatory cycle of events initiated by plaque biofilm generates a similar sequence of events that leads to destruction of the supporting structures of the periodontium. The features of metabolic syndrome and type 2 diabetes mellitus in periodontal patients constitute risk factors for cardiovascular disease with common risk markers such as IL-6, TNF-α, C-reactive protein and low density lipoprotein; the inflammatory burden imposed by periodontal disease contributes to endothelial dysfunction common to both diabetes mellitus and cardiovascular disease. It is relevant that management of periodontal disease leads to significant reduction in pro-inflammatory cytokines and acute phase proteins associated with endothelial dysfunction and cardiovascular pathology. In addition to reducing the inflammatory burden simultaneous control of metabolic factors affecting lipid metabolism appears to be significant for optimal therapeutic benefit. The potential contribution of periodontal disease to mortality and morbidity arising from systemic diseases warrants a stringent approach to its management. This article includes an appraisal of patents and patent applications that explores therapeutic strategy for dyslipidaemia, cardiovascular disease and diabetes mellitus in periodontal patients.

Keywords: Periodontology; inflammation; periodontal pathogens; high density / low density lipoproteins; hyperglycaemia; dyslipidaemia; pathological mechanisms; therapeutic targets

Document Type: Research article

Publication date: 2009-11-01

More about this publication?

• Recent Patents on Endocrine, Metabolic & Immune Drug Discovery publishes review articles by experts on recent patents in the field of endocrine, metabolic and immune drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in endocrine, metabolic and immune drug design and discovery.

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