Heat Shock Proteins And Neuroprotection

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Abstract:

Heat shock proteins (HSPs) (also known as stress proteins) protect the cells from damages caused due to different stresses like heat, injury, chemical induced toxicity, etc. Some HSPs can act as molecular chaperones to help in correct folding of proteins or directing misfolded proteins for degradation. This action prevents toxic accumulation of proteins in cells that can otherwise lead to damage and then death. Correct folding of proteins is essential for all cells but in particular, it is known that improper folding of proteins in neurons can lead to diseases like Alzheimer's, Parkinson's, polyglutamine (polyQ) diseases etc. This review focuses on patents that deal with direct or indirect applications of HSPs to prevent neurodegeneration or diagnosing neuropathy.





Keywords: Heat Shock Protein (HSP); antigen; enhanced levels; neuroprotection; transcription factor; vaccine

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187221507780887054

Publication date: June 1, 2007

More about this publication?
  • Recent Patents on DNA and Gene Sequences publishes review articles by experts on recent patents on DNA and gene sequences. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in applied molecular biology.
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