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The Importance of Bio-Computational Tools for Predicting HIV Drug Resistance

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Abstract:

The battle against retrovirus HIV-1 has reached a critical point. Antiretroviral resistance appears under highly active anti-retroviral therapy and the use of new drug combinations capable to overcome the emerged resistance is necessary. After detecting drug resistance two main approaches are possible. The phenotypic assays study in vitro the replication ability of virus variants in the presence or absence of drugs. This approach is expensive and time consuming. The genotypic assays try to obtain information from viral sequences coding for the drug targets in order to detect mutations with low susceptibility to drugs. Although this approach is faster and cheaper, a clear interpretation of the results is not always possible. In this work, I comment and analyze some new patents that point towards more efficient resistance detection and integral data management and prediction systems performing an efficient personalized combined therapy. In the future, computational tools will be essential as exploratory and interpretation systems in order to obtain a better support of clinical decisions concerning both the prediction and the evolution of drug resistance. Importantly, the revised patents conform to this trend.





Keywords: HIV-1; antiretroviral therapy; drug resistance test; protease inhibitors

Document Type: Research Article

DOI: https://doi.org/10.2174/187221507779814452

Affiliations: Departamento de Bioquimica, Genetica e Inmunologia. Universidad de Vigo, 36310 Vigo, Spain.

Publication date: 2007-02-01

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  • Recent Patents on DNA and Gene Sequences publishes review articles by experts on recent patents on DNA and gene sequences. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in applied molecular biology.
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