Advanced Nanotechnological Approaches for Designing Protein-Based “Lab-on-Chips” Sensors on Porous Silicon Wafer

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Abstract:

In this article, we will review the more recent patented approaches related to the design and development of micro- and nano-patterns of biomolecules on solid substrates for the realization of innovative biochips, including inkjet and spotting technology, and Scanning Probe Methods In addition, we will report on some important patents based on the use of porous materials as substrates, exploiting the large specific surface for the design of highly sensitive biodevices. The main advantages and drawbacks related to each technological approach to the biochips fabrication will be pointed out, and future perspectives in the field will be discussed.





Keywords: Atomic force microscopy; Biosensors; bioarray; biochip; nanolithography; nanotubes; porous silicon; proteins

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187221507779814470

Affiliations: Istituto di Biochimica delle Proteine, Consiglio Nazionale delle Ricerche, Via Pietro Castellino, 111, 80131 Naples, Italy.

Publication date: February 1, 2007

More about this publication?
  • Recent Patents on DNA and Gene Sequences publishes review articles by experts on recent patents on DNA and gene sequences. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in applied molecular biology.
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