Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals

Authors: Moling, Oswald; Rimenti, Giovanni; Pristera, Raffaele; Vedovelli, Claudio; Pagani, Leonardo; Spoladore, Greta; Mian, Peter

Source: Drug Metabolism Letters, Volume 3, Number 3, August 2009 , pp. 176-180(5)

Publisher: Bentham Science Publishers

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Abstract:

A 43 year old man with HIV and HCV infection and liver cirrhosis developed fatal lactic acidosis within five days from starting nifedipine for arterial hypertension. Multiple drug interactions, current and accumulated drug toxicities and the reduced liver function, might in combination have led to the acute lactic acidosis.

Keywords: Lactic acidosis; nifedipine; disulfiram; amitriptyline; ritonavir; HIV

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187231209789352120

Publication date: 2009-08-01

More about this publication?

Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.