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Drug Testing by Chemical Analysis of Fingerprint Deposits from Methadone- Maintained Opioid Dependent Patients Using UPLC-MS/MS

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Abstract:

Chemical analysis of fingerprint deposits from methadone-maintained opioid-dependent patients by UPLCMS/ MS show detectable levels of methadone and its metabolite, EDDP, demonstrating intake of the drug.





Keywords: Chemical analysis; EDDP; UPLCMS/ MS; drug; fingerprint; metabolite; methadone; opioid

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187231208786734094

Publication date: December 1, 2008

More about this publication?
  • Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.
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