ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan

Authors: Rhodes, Katrin E.1; Zhang, Wu1; Yang, Dongyun1; Press, Oliver A.1; Gordon, Michael1; Vallbohmer, Daniel1; Schultheis, Anne M.1; Lurje, Georg1; Ladner, Robert D.1; Fazzone, William1; Lenz, Heinz-Josef1; Iqbal, Syma1

Source: Drug Metabolism Letters, Volume 1, Number 1, January 2007 , pp. 23-30(8)

Publisher: Bentham Science Publishers

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

Keywords: Polymorphisms; colorectal cancer; toxicity; irinotecan

Document Type: Research article

DOI: 10.2174/187231207779814328

Affiliations: 1: Oncology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, Los Angeles, CA 90033, USA.

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A