Comparison of Paraben Stability in Human and Rat Skin

Authors: Harville, Heather M.¹; Voorman, Richard¹; Prusakiewicz, Jeffery J.¹

Source: Drug Metabolism Letters, Volume 1, Number 1, January 2007 , pp. 17-21(5)

Publisher: Bentham Science Publishers

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Abstract:

Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.

Keywords: Paraben; esterase; skin; epidermal drug metabolism

Document Type: Research article

DOI: 10.2174/187231207779814300

Affiliations: 1: 2800 Plymouth Rd. 20/342S-D,Ann Arbor, MI 48105, USA.

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