Comparison of Paraben Stability in Human and Rat Skin

Authors: Harville, Heather M.; Voorman, Richard; Prusakiewicz, Jeffery J.

Source: Drug Metabolism Letters, Volume 1, Number 1, January 2007 , pp. 17-21(5)

Publisher: Bentham Science Publishers

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Abstract:

Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.

Keywords: Paraben; esterase; skin; epidermal drug metabolism

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187231207779814300

Affiliations: 1: 2800 Plymouth Rd. 20/342S-D,Ann Arbor, MI 48105, USA.

Publication date: 2007-01-01

More about this publication?

Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.