In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Authors: H. Chang, Thomas K.; Chen, Jie; Yu, Chia-Ting

Source: Drug Metabolism Letters, Volume 1, Number 1, January 2007 , pp. 13-16(4)

Publisher: Bentham Science Publishers

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Abstract:

Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.

Keywords: CYP1A1; CYP1A2; cytochrome P450; piceatannol; trans-resveratrol

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187231207779814337

Affiliations: 1: Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver,BC, V6T 1Z3, Canada.

Publication date: 2007-01-01

More about this publication?

Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.