In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Authors: H. Chang, Thomas K.¹; Chen, Jie¹; Yu, Chia-Ting¹

Source: Drug Metabolism Letters, Volume 1, Number 1, January 2007 , pp. 13-16(4)

Publisher: Bentham Science Publishers

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Abstract:

Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.

Keywords: CYP1A1; CYP1A2; cytochrome P450; piceatannol; trans-resveratrol

Document Type: Research article

DOI: 10.2174/187231207779814337

Affiliations: 1: Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver,BC, V6T 1Z3, Canada.

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