Skip to main content

Systemic Delivery of siRNA: Challenging but Promising

Buy Article:

$113.00 plus tax (Refund Policy)

Abstract:

Small interfering RNA (siRNA) is a small, double-stranded RNA molecule that can suppress expression of specific genes. It will be a promising therapeutic agent for the treatment of viral and genetic diseases, such as HIV infection and cancer. However, it is extremely challenging to systemically deliver siRNA to the intended sites of action due to a variety of extracellular and intracellular barriers. Over the past decade, many novel patents have been developed to improve delivery efficiency and therapeutic efficacy of siRNA. The features of the carriers and technologies for systemic delivery of siRNA in these patents are summarized, and their clinical applications are discussed in this review.





Keywords: Conjugates; Endosomal Escape; Lipid-based Delivery; Polymer-based Delivery; drug targeting; lipoplex; nanoparticles; polyplex; siRNA delivery; systemic delivery

Document Type: Research Article

Publication date: April 1, 2012

More about this publication?
  • Recent Patents on Drug Delivery and Formulation publishes review articles by experts on recent patents on drug delivery and formulation. A selection of important and recent patents on drug delivery and formulation is also included in the journal. The journal is essential reading for all researchers involved in the fields of drug delivery and formulation.
ben/ddf/2012/00000006/00000001/art00003
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more