New Methods for Lipid Nanoparticles Preparation
Authors: Corrias, Francesco; Lai, Francesco
Source: Recent Patents on Drug Delivery & Formulation, Volume 5, Number 3, September 2011 , pp. 201-213(13)
Publisher: Bentham Science Publishers
Abstract:Lipid nanoparticles have attracted many researchers during recent years due to the excellent tolerability and advantages compared to liposomes and polymeric nanoparticles. High pressure homogenization is the main technique used to prepare solid lipid nanoparticles (SLN) encapsulating different type of drugs, however this method involves some critical process parameters. For this reason and in order to overcome patented methods, different production techniques for lipid nanoparticles have been widely investigated in recent years (last decade). The paper reviews new methods for lipid nanoparticles preparation, and their recent applications in pharmaceutical field, especially focusing on coacervation, microemulsions templates, supercritical fluid technology, phase-inversion temperature (PIT) techniques. References of the most relevant literature and patents published by various research groups on these fields are provided.
Keywords: Coacervation; Gasco Method; MICROEMULSION TEMPLATES METHODS; MUMPER AND JAY METHOD; Membrane Contactor Method; PHASE INVERSION TEMPERATURE METHOD; microemulsions template; phase inversion temperature (PIT) techniques; solid lipid nanoparticles; supercritical fluid technology
Document Type: Research Article
Publication date: September 1, 2011
- Recent Patents on Drug Delivery and Formulation publishes review articles by experts on recent patents on drug delivery and formulation. A selection of important and recent patents on drug delivery and formulation is also included in the journal. The journal is essential reading for all researchers involved in the fields of drug delivery and formulation.