Current Topics in Medicinal Chemistry

Editorial (Hot Topic: Protein Misfolding in Conformational Disorders)
pp. 2459-2459(1)
Author: M. Gomes, Claudio

Protein Misfolding in Disease and Small Molecule Therapies
pp. 2460-2469(10)
Author: M. Gomes, Claudio

Aggregation Prone Regions and Gatekeeping Residues in Protein Sequences
pp. 2470-2478(9)
Authors: Beerten, Jacinte; Schymkowitz, Joost; Rousseau, Frederic

DNAJ Proteins and Protein Aggregation Diseases
pp. 2479-2490(12)
Authors: Kakkar, Vaishali; C. B. Prins, Louis; H. Kampinga, Harm

Molecular Chaperone Disorders: Defective Hsp60 in Neurodegeneration
pp. 2491-2503(13)
Authors: Bross, Peter; Magnoni, Raffaella; Sigaard Bie, Anne

On the Design of Broad Based Screening Assays to Identify Potential Pharmacological Chaperones of Protein Misfolding Diseases
pp. 2504-2522(19)
Authors: Naik, Subhashchandra; Zhang, Na; Gao, Phillip; T. Fisher, Mark

Amyloid Formation in Light Chain Amyloidosis
pp. 2523-2533(11)
Author: Ramirez-Alvarado, Marina

Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones
pp. 2534-2545(12)
Authors: Underhaug, Jarl; Aubi, Oscar; Martinez, Aurora

Cofactors and Metabolites as Protein Folding Helpers in Metabolic Diseases
pp. 2546-2559(14)
Authors: V. Rodrigues, Joao; J. Henriques, Barbara; G. Lucas, Tania; M. Gomes, Claudio

SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status
pp. 2560-2572(13)
Authors: Sheng, Yuewei; Chattopadhyay, Madhuri; Whitelegge, Julian; Selverstone Valentine, Joan

Copper and Heme-Mediated Abeta Toxicity: Redox Chemistry, Abeta Oxidations and Anti-ROS Compounds
pp. 2573-2595(23)
Authors: Chassaing, Stefan; Collin, Fabrice; Dorlet, Pierre; Gout, Jerome; Hureau, Christelle; Faller, Peter

Insights into Aβ Aggregation: A Molecular Dynamics Perspective
pp. 2596-2610(15)
Authors: Shea, Joan-Emma; Urbanc, Brigita

Putting Huntingtin “Aggregation” in View with Windows into the Cellular Milieu
pp. 2611-2622(12)
Author: M. Hatters, Danny

Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation
pp. 2623-2640(18)
Authors: Calamini, Barbara; I. Morimoto, Richard