Current Status of Carbapenem Antibiotics
Authors: I. El-Gamal, Mohammed; Oh, Chang-Hyun
Source: Current Topics in Medicinal Chemistry, Volume 10, Number 18, December 2010 , pp. 1882-1897(16)
Publisher: Bentham Science Publishers
Abstract:β-Lactam antibiotics are the most prescribed antibacterial agents. They comprise more than half of all antibiotics. They are considered as the cornerstone of the antibiotic armamentarium. By inhibiting bacterial cell wall biosynthesis, they are highly effective against Gram-positive and Gram-negative bacteria. Antibiotic resistance among Gram-negative pathogens in hospitals represents a dangerous threat to public health. Since many bacteria have developed resistance to older agents, new β-lactam antibiotics have been continuously developed. In the late 1970s, a new class of exceptionally broad-spectrum non-traditional β-lactams, carbapenems, was developed. This review article focuses on the new developments related to the field of carbapenems for treatment of bacterial infections, especially those caused by Gram-negative bacteria. The structural features, principal characteristics, and clinical implications of carbapenems including thienamycin, imipenem/cilastatin, panipenem/betamipron, biapenem, tebipenem, tebipenem pivoxil, meropenem, ertapenem, doripenem, lenapenem, and tomopenem are discussed herein.
Keywords: 1--Methylcarbapenems containing pyrrolidin-3-ylthio moiety; 1--Methylcarbapenems lacking pyrrolidin-3-ylthio moiety; 1--methyl group; Alanine transaminase; Alkaline phosphatase; AmpC -lactamase resistance mechanisms; Aspartate transaminase; Carbapenem; Carbapenems; Carbapenems lacking 1-methyl group; DHP-I spe-cific inhibitor; Dehydropeptidase-I; Gram-negative bacteria; Gram-positive; Lactam antibiotics; MK-0826; N-acetyl derivative; N-formimidoyl derivative; OprD porins; Trans-1-Hydroxyethyl Substituent; aerobic and anaerobic bacteria; alanine transaminase; ami-kacin; amine or amidine moieties; antibacterial agents; aspar-gine-132; asparenomycins; aspartate transa-minase; biapenem; broad-spectrum; carbapenemases; carboxylic acid moiety; carpetimycins; cephalosporins; community-acquired infections; complicated intra-abdominal infections; complicated skin and skin-structure infections; cystic fibrosis; daptomycin; doripenem; ertapenem; faropenem; febrile neutropenia; hepatic transaminases; human renal DHP-I; hydrogen-bonding interaction; imipenem/cilastatin; intra-abdominal infections; lactamases; lactams; lenapenem; levofloxacin; line-zolid; meropenem; meta-substituted benzoic acid substituent; metallo--lacta-mases; multidrug resistance; nosocomial infections; olivanic acids; panipenem/betamipron; penicillin-binding proteins; penicillins; plasmid-mediated IMP-type carbapenemases; pluracidomycins; polymicrobial infections; tebipenem; tebipenem pivoxil; thienamycin; tomopenem; urinary tract infections; ventilator-associated pneumonia; β-lactamases; β-lactams
Document Type: Research Article
Publication date: 2010-12-01