Current Topics in Medicinal Chemistry

Editorial [Hot topic: Medicinal Chemistry in the Pilot Phase of the Molecular Libraries Screening Center Network (Guest Editor: Donna M. Huryn)]
pp. 1158-1158(1)
Author: Huryn, Donna M.

Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining
pp. 1159-1171(13)
Authors: Thepchatri, Pahk; Min, Jaeki; Ganesh, Thota; Du, Yuhong; Lewis, Iestyn; Kurtkaya, Serdar; Prussia, Andrew; Li, Lian; Sneed, Blossom; Plemper, Richard K.; Fu, Haian; Liotta, Dennis C.; Snyder, James P.; Dingledine, Raymond; Sun, Aiming

Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay
pp. 1172-1180(9)
Authors: Xie, Yuli; Rinderspacher, Alison; Liu, Yidong; Gong, Gangli; Smith, Deborah H.; Wyler, Michael; Branden, Lars; Deng, Shi-Xian

The Pilot Phase of the NIH Chemical Genomics Center
pp. 1181-1193(13)
Authors: Thomas, Craig J.; Auld, Douglas S.; Huang, Ruili; Huang, Wenwei; Jadhav, Ajit; Johnson, Ronald L.; Leister, William; Maloney, David J.; Marugan, Juan J.; Michael, Sam; Simeonov, Anton; Southall, Noel; Xia, Menghang; Zheng, Wei; Inglese, James; Austin, Christopher P.

A Case Study from the Chemistry Core of the Pittsburgh Molecular Library Screening Center: The Polo-like Kinase Polo-Box Domain (Plk1- PBD)
pp. 1194-1205(12)
Authors: Wipf, Peter; Arnold, David; Carter, Karen; Dong, Shuzhi; Johnston, Paul A.; Sharlow, Elizabeth; Lazo, John S.; Huryn, Donna H.

The Identification, Characterization and Optimization of Small Molecule Probes of Cysteine Proteases: Experiences of the Penn Center for Molecular Discovery with Cathepsin B and Cathepsin L
pp. 1206-1216(11)
Authors: Huryn, Donna M.; Smith III, Amos B.

Discovery and Development of a Potent and Highly Selective Small Molecule Muscarinic Acetylcholine Receptor Subtype I (mAChR 1 or M1) Antagonist In Vitro and In Vivo Probe
pp. 1217-1226(10)
Authors: Weaver, C. D.; Sheffler, Douglas J.; Lewis, L. M.i.c.h.e.l.l.e.; Bridges, Thomas M.; Williams, Richard; Nalywajko, Natalia T.; Kennedy, J. P.h.i.l.l.i.p.; Mulder, Matthew M.; Jadhav, Satyawan; Aldrich, Leslie A.; Jones, Carrie K.; Marlo, Joy; Niswender, Colleen M.; Mock, Matthew M.; Zheng, Fang; Conn, P. J.e.f.f.r.e.y.; Lindsley, Craig W.

Discovery of Selective Probes and Antagonists for G Protein-Coupled Receptors FPR/FPRL1 and GPR30
pp. 1227-1236(10)
Authors: Arterburn, Jeffrey B.; Oprea, Tudor I.; Prossnitz, Eric R.; Edwards, Bruce S.; Sklar, Larry A.