Structure-Based Drug Design Strategies in Medicinal Chemistry
A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design (SBDD) methods are becoming increasingly powerful, versatile and more widely used. This review summarizes current developments in structure-based virtual screening and receptor-based pharmacophores, highlighting achievements as well as challenges, along with the value of structure-based lead optimization, with emphasis on recent examples of successful applications for the identification of novel active compounds.
Keywords: QSAR; Structure-based drug design; medicinal chemistry; pharmacophores; virtual screening
Document Type: Research Article
Affiliations: Laboratorio de Quimica Medicinal e Computacional, Centro de Biotecnologia Molecular Estrutural, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av. Trabalhador Sao-Carlense 400, 13560-970 Sao Carlos-SP, Brazil.
Publication date: 01 June 2009
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