Soluble Epoxide Hydrolase, a Target with Multiple Opportunities for Cardiovascular Drug Discovery

Author: Marino Jr., Joseph P.

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 5, April 2009 , pp. 452-463(12)

Publisher: Bentham Science Publishers

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Abstract:

Soluble epoxide hydrolase (sEH) is a cross-functional target, with the potential for therapeutic utility in the areas of hypertension, inflammation, and organ-protection [1]. Promising target validation has emerged around soluble epoxide hydrolase in recent years which suggests that small molecule inhibitors may have utility in cardio protection, glucose regulation, hypertension, inflammation, and organ protection. Based on the diversity of chemical classes of sEH inhibitors reported in the literature, there exists a real opportunity to definitively determine the best therapeutic utility for an sEH inhibitor. Recent advances in target validation and tool compounds from medicinal chemistry efforts will be described.

Keywords: Soluble epoxide hydrolase; epoxyeicosatrienoic acids; EETs; dihydroxyeicosatrienoic acids; DHETs; P450 monooxygenase; Ephx2

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156802609788340805

Affiliations: 1: Metabolic Pathways Center of Excellence in Drug Discovery, Glaxo-SmithKline Research and Development, 709 Swedeland Rd., King of Prussia, PA 19406, USA.

Publication date: 2009-04-01