Medicinal Chemistry Approaches to the Inhibition of Dipeptidyl Peptidase IV

Author: Gwaltney II, Stephen L.

Source: Current Topics in Medicinal Chemistry, Volume 8, Number 17, November 2008 , pp. 1545-1552(8)

Publisher: Bentham Science Publishers

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Abstract:

Inhibitors of dipeptidyl peptidase IV (DPP-4) have emerged as an important new class of therapeutic agents for type two diabetes. Various medicinal chemistry approaches have been applied to this area and have resulted in the identification of numerous late-stage development compounds. The discoveries of several of the most advanced DPP-4 inhibitors are reviewed.

Keywords: Dipeptidyl Peptidase IV (DPP-4); Glucagon-like Peptide-1 (GLP-1); vildagliptin (Galvus®); saxagliptin (Onglyza™); sitagliptin (Januvia™); linagliptin (Ondero®); alogliptin

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156802608786413519

Affiliations: 1: Takeda San Diego, 10410 Science Center Drive, San Diego, CA 92121.

Publication date: 2008-11-01