Current Topics in Medicinal Chemistry

Editorial [Hot topic: Medicinal Chemistry Strategies to Minimize hERG Channel Effects 23 May (Guest Editor:Mark T. Bilodeau)]
pp. 1101-1101(1)
Author: Bilodeau, Mark T.

The hERG Channel and Risk of Drug-Acquired Cardiac Arrhythmia: An Overview
pp. 1102-1112(11)
Authors: Lagrutta, Armando A.; Trepakova, Elena S.; Salata, Joseph J.

Ligand Structural Aspects of hERG Channel Blockade
pp. 1113-1127(15)
Author: Aronov, Alex M.

The Impact of IKr Blockade on Medicinal Chemistry Programs
pp. 1128-1139(12)
Authors: Bell, Ian M.; Bilodeau, Mark T.

Overcoming hERG Affinity in the Discovery of Maraviroc; A CCR5 Antagonist for the Treatment of HIV
pp. 1140-1151(12)
Authors: Price, David A.; Armour, Duncan; de Groot, Marcel; Leishman, Derek; Napier, Carolyn; Perros, Manos; Stammen, Blanda L.; Wood, Anthony

Lead Optimization of Melanin Concentrating Hormone Receptor 1 Antagonists with low hERG Channel Activity
pp. 1152-1157(6)
Authors: Judd, Andrew S.; Souers, Andrew J.; Kym, Philip R.

Molecule of the Month
pp. 1158-1158(1)
Author: Lindsley, Craig W.