Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1

Author: Bednarek, Maria A.

Source: Current Topics in Medicinal Chemistry, Volume 7, Number 15, August 2007 , pp. 1425-1432(8)

Publisher: Bentham Science Publishers

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Abstract:

The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents.

Keywords: Melanin-concentrating hormone; melanin-concentrating hormone receptor; antagonist; obesity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156802607782194734

Affiliations: 1: Merck Research Laboratories,R50G-140, 126 East Lincoln Avenue, Rahway, NJ 07065, USA.

Publication date: 2007-08-01