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The Emerging Role of the Histamine H4 Receptor in Anti-inflammatory Therapy

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Antagonists for the Histamine H 1 receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H4 receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H4 receptor as a drug target.
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Keywords: Asthma; Inflammation; Inflammatory Bowel Disease (IBD); JNJ 7777120; Rheumatoid arthritis; benzimidazole scaffold

Document Type: Research Article

Affiliations: Leiden/Amsterdam Center of Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV,Amsterdam, The Netherlands.

Publication date: 2006-07-01

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