Current Topics in Medicinal Chemistry

Editorial [Hot Topic:Successful Drug Discovery: Rules and Examples (Guest Editor: Dr. David C. Swinney)]
pp. 403-404(2)
Author: Swinney, David C.

Discovery and Clinical Development of Dutasteride, a Potent Dual 5α- Reductase Inhibitor
pp. 405-421(17)
Author: Frye, Stephen V.

Optimization of Small Molecule Drugs Binding to Highly Polar Target Sites: Lessons from the Discovery and Development of Neuraminidase Inhibitors
pp. 423-434(12)
Authors: Klumpp, Klaus; Graves, Bradford J.

Lessons from the Drug Discovery of Lapatinib, a Dual ErbB1/2 Tyrosine Kinase Inhibitor
pp. 435-460(26)
Author: Lackey, Karen E.

Biochemical Mechanisms of New Molecular Entities (NMEs) Approved by United States FDA During 2001-2004: Mechanisms Leading to Optimal Efficacy and Safety
pp. 461-478(18)
Author: Swinney, David C.

A Medicinal Chemistry Perspective on 4-Aminoquinoline Antimalarial Drugs
pp. 479-507(29)
Authors: O' Neill, Paul M.; Ward, Stephen A.; Berry, Neil G.; Jeyadevan, J. P.; Biagini, Giancarlo A.; Asadollaly, Egbaleh; Park, B. K.; Bray, Patrick G.

From Artemisinin to New Artemisinin Antimalarials: Biosynthesis, Extraction, Old and New Derivatives, Stereochemistry and Medicinal Chemistry Requirements
pp. 509-537(29)
Author: Haynes, Richard K.

Mechanisms of Drug Action and Drug Resistance in Leishmania as Basis for Therapeutic Target Identification and Design of Antileishmanial Modulators
pp. 539-550(12)
Authors: Loiseau, Philippe M.; Bories, Christian