Author: Findeis, M.A.

Source: Current Topics in Medicinal Chemistry, Volume 2, Number 4, 1 April 2002 , pp. 417-423(7)

Publisher: Bentham Science Publishers

Abstract:

Amyloid beta peptide (A) is implicated in the pathogenesis of Alzheimer's disease (AD), particularly as oligomers or polymers that are correlated with Ab cellular toxicity. Inhibition of the formation of toxic forms of A has therefore emerged as one approach to the treatment of AD. This article reviews efforts to adapt the structure of Ato the design and testing of peptide-based inhibitors of A polymerization of interest as potential AD therapeutics.

Keywords: Peptide Inhibitors; Beta Amyloid Aggregation; Amyloid beta peptide

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1568026024607508

Publication date: 2002-04-01

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