Peptide Inhibitors of Beta Amyloid Aggregation

Author: Findeis, M.A.

Source: Current Topics in Medicinal Chemistry, Volume 2, Number 4, 1 April 2002 , pp. 417-423(7)

Publisher: Bentham Science Publishers

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Abstract:

Amyloid beta peptide (Abgr) is implicated in the pathogenesis of Alzheimer's disease (AD), particularly as oligomers or polymers that are correlated with Ab cellular toxicity. Inhibition of the formation of toxic forms of Abgr has therefore emerged as one approach to the treatment of AD. This article reviews efforts to adapt the structure of Abgrto the design and testing of peptide-based inhibitors of Abgr polymerization of interest as potential AD therapeutics.

Keywords: Peptide Inhibitors; Beta Amyloid Aggregation; Amyloid beta peptide

Document Type: Review article

DOI: 10.2174/1568026024607508

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