Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

Authors: Shoemaker, R.H.; Scudiero, D.A.; Melillo, G.; Currens, M.J.; Monks, A.P.; Rabow, A.A.; Covell, D.G.; Sausville, E.A.

Source: Current Topics in Medicinal Chemistry, Volume 2, Number 3, 1 March 2002 , pp. 229-246(18)

Publisher: Bentham Science Publishers

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Abstract:

Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology,”rational“ drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.

Keywords: anticancer drug discovery; molecular medicine; (cat) assays

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1568026023394317

Publication date: 2002-03-01