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In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders.

The aim of this journal is to publish timely in-depth reviews as well as original papers in the field of signal transduction therapy. Thematic issues will also be published to cover selected areas of signal transduction therapy. Coverage of the field will include genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases.

Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.

Publisher: Bentham Science Publishers

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Volume 5, Number 1, 2010

Articles

Preface
pp. i-i(1)
Authors: Keri, Gyorgy; Ullrich, Axel

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Metabolic Regulation by the Hexosamine Biosynthesis/O-Linked N-Acetyl Glucosamine Pathway
pp. 3-11(9)
Authors: McClain, Donald A.; Taylor, Rodrick P.; Soesanto, Yudi; Luo, Bai

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The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression
pp. 12-24(13)
Authors: Brimble, Sandii; Wollaston-Hayden, Edith E.; Teo, Chin F.; Morris, Andrew C.; Wells, Lance

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Immune Regulation by the Posttranslational Modification O-GlcNAc
pp. 41-48(8)
Authors: Pappa, Alexander; Guerini, Danilo

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Protein O-GlcNAcylation: A Critical Regulator of the Cellular Response to Stress
pp. 49-59(11)
Authors: Chatham, John C.; Marchase, Richard B.

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C. elegans Genetic Networks Predict Roles for O-GlcNAc Cycling in Key Signaling Pathways
pp. 60-73(14)
Authors: Mondoux, Michelle A.; Krause, Michael W.; Hanover, John A.

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Free Content Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes
pp. 74-91(18)
Authors: Gloster, Tracey M.; Vocadlo, David J.

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