The Role of Stroma in Hematopoiesis and Dendritic Cell Development

Authors: Despars, Genevieve; Tan, Jonathan; Periasamy, Pravin; O'Neill, Helen C.

Source: Current Stem Cell Research & Therapy, Volume 2, Number 1, January 2007 , pp. 23-29(7)

Publisher: Bentham Science Publishers

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Abstract:

Development of the immune system is depicted as a hierarchical process of differentiation from hematopoietic stem cells (HSC) to lineage-committed precursors, which further develop into mature immune cells. In the case of dendritic cell (DC) development, this linear precursor-progeny approach has led to a confused picture of relationships between various subsets of DC identifiable in vivo. A possible reconciliation of the diversity of DC precursors and DC subsets in vivo encompasses the role of the microenvironment in DC hematopoiesis. We propose here that various niches for DC hematopoiesis within lymphoid organs could account for the diversity of DC in vivo. A tridimensional space consisting of stromal cells which produce a range of membrane-bound and secreted molecules providing signals to DC progenitors would define these niches

Keywords: Niche; endothelial cells; hematopoiesis; dendritic cells

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157488807779317017

Affiliations: 1: School of Biochemistry and Molecular Biology, Building #41, Linnaeus Way, Australian National University, Canberra, ACT, 0200, Australia.

Publication date: 2007-01-01

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Current Stem Cell Research & Therapy publishes frontier reviews on all aspects of basic research on stem cells and their uses in clinical therapy. The journal's aim is to publish the highest quality review articles in the field. The journal is essential reading for all researchers and clinicians involved in stem cells.