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Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells

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Abstract:

The cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is also welldocumented. However, LIF is not involved in self-renewal of human ES cells, suggesting that other pathways must play an important role in this process. The importance of other signal transduction pathways, including BMP and Wnt signalings, as well as novel transcription factors such as Nanog, is now being recognized. We will review the rapid progress that has been made in identifying and dissecting the intracellular signaling pathways that contribute to self-renewal of pluripotent mouse and human ES cells.





Keywords: Crosstalk; Cytokine; Growth factor; Regenerative medicine; Transcription factor

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/157488806775269061

Publication date: January 1, 2006

More about this publication?
  • Current Stem Cell Research & Therapy publishes frontier reviews on all aspects of basic research on stem cells and their uses in clinical therapy. The journal's aim is to publish the highest quality review articles in the field. The journal is essential reading for all researchers and clinicians involved in stem cells.

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