Skip to main content

Psoriatic Arthritis – Review of the Immunologic, Clinic and Therapeutic Aspects of an Inflammatory Systemic Disease

Buy Article:

$55.00 plus tax (Refund Policy)

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. It may affect the peripheral joints, the spine and the entheses. Over the past several decades it revealed itself as a systemic disease as severe as Rheumatoid Arthritis (RA) though it is most of the times seronegative for rheumatoid factor. PsA causes impressive inflammation, deformities and joint damage leading to impaired quality of life and function. It is associated with increased morbidity and mortality risk. We have better insight into the inflammatory and immunologic mechanism involved in this condition, the inflammatory cells, cytokines, adhesion molecules which helped finding the targets for treatment. Over a decade ago with the discovery of the anti-tumor necrosis factor alpha (TNFα) inhibitors we finally found the treatment to reduce the progression of joint damage. Starting this treatment early in the course of disease prevents the joint damage, improves the functional capacity and the survival of the patients with PsA. The biologic medications are effective in reducing dactylitis and enthesitis which are rarely improved by conventional treatments.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Psoriatic arthritis; biologic treatment; enthesitis; spondylarthropathy; synovitis; tumor necrosis alpha

Document Type: Research Article

Publication date: 2012-02-01

More about this publication?
  • Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

    The journal is essential reading for all researchers and clinicians in rheumatology.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more