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Update on the Management of Systemic Lupus Erythematosus from a Pediatric Nephrology Perspective

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Abstract:

Although systemic lupus erythematosus (SLE) has a peak incidence in young women, the disease often first presents during childhood. Moreover studies have suggested that patients with disease onset in childhood have a worse prognosis. Considering that renal involvement in SLE is the major determinant of long-term survival and morbidity, the focus of this article will be to review new and exciting approaches in the treatment of pediatric lupus nephritis by referencing the major studies over the last few years. Since membranous lupus nephritis is very different from other forms of lupus nephritis, the treatment of this specific form of renal involvement will not be discussed in great detail. Very few robust clinical trials have investigated the treatment of SLE and lupus nephritis in the pediatric population; hence most recommendations are based on adult clinical trials.

Keywords: Lupus; Lupus nephritis; Nephritis; SLE; Therapy; outcomes; pediatrics

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/157339712801318984

Publication date: February 1, 2012

More about this publication?
  • Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

    The journal is essential reading for all researchers and clinicians in rheumatology.

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