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Evolution and Analysis of Heterogeneity in the Clinical Expression of Aortic Diseases Similar to Marfan’s Syndrome: Challenge and Art in Clinical Diagnosis

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Abstract:

Introduction: Marfan’s syndrome (MFS) is a dominant autosomal connective tissue disease that affects eyes, musculo-skeletal and cardiovascular systems. The initial evaluation must be meticulous. Because there are discrete clinical data only in aortic diseases similar to MFS. Objective: To conduct a retrospective evaluation of the diagnostic criteria applied upon admission of patients with MFS, the evolution of aortic deterioration, surgery, and survival over a period from 1983 to 2008. Material and Methods: Clinical, surgical and pathological records of patients diagnosed with Marfan’s syndrome were examined. Clinical findings, classification, established diagnoses, initial manifestations, duration of the disease, pathological findings, therapy, and survival were all re-evaluated. Results: A total of 166 patient files were studied. Seventy-eight had family histories of MFS. Seven did not fulfill the criteria for MFS, two might correspond to Shprintzen-Goldberg syndrome, three to Ehlers-Danlos syndrome, and two to Loeys-Dietz syndrome. Surgeries were performed in 63 adults. The survival rate of patients with aortic dilatation was 70% at 12 years. Survival diminished with aortic dissection. The mortality of the entire population was 14%. Conclusions: The evolution of MFS and other aortic diseases is variable. Cardiovascular damage is the factor that most commonly has an adverse effect on prognoses and must be under constant observation. Adding the Ghent criteria to clinical evaluation and attention to specific clinical findings can improve the classification of cases. Delays in diagnosis generally occur during the transition from adolescence to adulthood.

Keywords: Marfan’s syndrome; aortic dilatation; aortic dissection; fibrillinopathies; heterogenicity

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/157339712801318948

Publication date: February 1, 2012

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  • Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

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