Pentosidine, an Advanced Glycation Endproduct, and Arthritis

Author: Takahashi, Masaaki

Source: Current Rheumatology Reviews, Volume 2, Number 4, November 2006 , pp. 319-324(6)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $62.88 plus tax (Refund Policy)

Abstract:

Pentosidine is one of the advanced glycation end-products (AGEs). Its significant elevation was firstly observed in diabetes mellitus, and later found in patients with end-stage renal failure. In addition, during the aging process, pentosidine accumulates in the extracellular matrix and causes insolubility and protease resistance of extracellular matrix proteins. In cartilage, pentosidine is crosslinked in collagen and proteoglycan, and thus increases the stiffness of the cartilage. Carbonyl stress, oxidative stress and aging progress the formation and accumulation of pentosidine. In arthritis, a significant elevation of pentosidine was found in rheumatoid arthritis and moreover in osteoarthritis. This review will discuss the relationship between pentosidine and arthritis, and its role as a potential marker for arthritis.

Keywords: Pentosidine; advanced glycation end-products; AGE; osteoarthritis; rheumatoid arthritis; marker

Document Type: Research article

Affiliations: 1: Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.

Publication date: 2006-11-01

More about this publication?

Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

The journal is essential reading for all researchers and clinicians in rheumatology.