Antibiotics in the Treatment of Reactive Arthritis

Authors: Toivanen, Auli; Yli-Kerttula, Timo; Mottonen, Timo

Source: Current Rheumatology Reviews, Volume 2, Number 3, August 2006 , pp. 303-308(6)

Publisher: Bentham Science Publishers

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Abstract:

Reactive arthritis is triggered by an infection. Much of evidence has been accumulated to prove that the causative microbes or their components may persist in the organism for extended periods, maintaining an active immune response. Therefore, the question about the value of antibiotics has been entertained by several research groups. A number of studies have demonstrated that antibiotics may be useful only if applied very early, before the pathogenetic process has started. In established reactive arthritis short-term treatment is apparently not effective. Also a three-month course of ciprofloxacin has been demonstrated to be without clinical effect as observed during a one-year follow-up. The same findings were made in a large multicenter EULAR study regarding azithromycin. However, when patients were re-examined four to seven years after an initial 3-month course of the antibiotics in the Finnish ciprofloxacin study, it turned out that patients in the placebo group had significantly more often developed chronic joint symptoms and objective findings of rheumatic disease than those treated with the antibiotic. In addition, a recent study suggests that intensive treatment with a combination of doxycycline and rifampin may have a beneficial effect even in chronic reactive arthritis. The question must be raised whether antibiotics, after all, should be considered especially in HLA-B27 positive patients.

Keywords: Reactive arthritis; spondylarthrtopathies; enteroarthritis; uroarthritis; HLA-B27; ciprofloxacin

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339706778019575

Affiliations: 1: Department of Medicine,Turku University, FIN-20520 Turku, Finland.

Publication date: 2006-08-01

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Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

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Antibiotics in the Treatment of Reactive Arthritis

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