Can 5-HT3 Receptor Antagonists Replace Anesthetics and Corticosteroids in the Local Treatment of Rheumatic Processes?

Authors: Stratz, Thomas; Muller, Wolfgang

Source: Current Rheumatology Reviews, Volume 1, Number 3, November 2005 , pp. 295-298(4)

Publisher: Bentham Science Publishers

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Abstract:

A local injection of the 5-HT3 receptor antagonist tropisetron has a distinct analgesic effect on various local diseases of the locomotor system, such as tendinopathy, periarthropathy, trigger points and inflammatory articular processes. The effect of tropisetron matches that of commonly used local anesthetics like lidocaine, prilocaine and others, lasts much longer. Animal experimental and clinical findings seem to indicate that this prolonged action is most likely due to a concomitant antiinflammatory effect of the 5-HT3 receptor antagonist. It may therefore be assumed that this substance will at least partly be able to replace the administration of anesthetics and corticosteroids in the local treatment of rheumatic processes.

Keywords: 5-HT3 receptors; rheumatic diseases; corticosteroids; tropiset

Document Type: Review article

DOI: http://dx.doi.org/10.2174/157339705774612274

Affiliations: 1: Bergseestraße 61, D-79713 Bad Sackingen, Germany.

Publication date: 2005-11-01

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Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

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