Rhinovirus-Associated Wheeze During Infancy and Asthma Development

Authors: Jartti, Tuomas; E. Gern, James

Source: Current Respiratory Medicine Reviews, Volume 7, Number 3, June 2011 , pp. 160-166(7)

Publisher: Bentham Science Publishers

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Abstract:

Rhinovirus is commonly associated with bronchiolitis - only second to RSV during the first year life. The prevalence of HRV-bronchiolitis may be very high in predisposed infants. HRV diagnosis is almost exclusively based on PCR, which detects respiratory infections with or without symptoms. Two immunologic factors, interferon responses and atopy, have been associated with susceptibility to HRV-bronchiolitis in multiple studies. The current data supports the hypothesis that susceptibility to HRV-bronchiolitis is likely to be an early manifestation of biased immune responses, which are linked to both decreased viral defence and atopic airway inflammation. Prospective studies have consistently shown that early wheezing associated with HRV infection is closely associated with recurrent wheezing and the development of asthma in children. Collectively, these studies suggest that HRV infection in wheezing children could serve as a clinically useful marker for early identification of asthma prone children. The findings to date provide the rationale for future studies to incorporate rhinovirus illnesses into asthma risk indices.

Keywords: Wheezing; bronchiolitis; asthma; rhinovirus; respiratory syncytial virus; prognosis; infant; child; PCR; respiratory infections; interferon

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339811795589423

Publication date: 2011-06-01

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Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.