Clinical Uses of Heliox Mixtures in Chronic Obstructive Pulmonary Disease

Authors: Koulouris, Nickolaos G.; Koutsoukou, Antonia; D'Angelo, Edgardo

Source: Current Respiratory Medicine Reviews, Volume 5, Number 3, August 2009 , pp. 168-173(6)

Publisher: Bentham Science Publishers

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Abstract:

The use of helium in medicine was first described by Barach who treated obstructive lesions of the airways, in 1936. Since then, only scattered reports can be found in the medical literature until the 80's, when interest in helium resurged for the treatment of acute asthma, as deaths from this disease begun to rise. At least theoretically, because of its physical properties, helium should be useful in several obstructive conditions of the airways including upper airway obstruction, croup, post-extubation stridor, asthma attacks, exacerbations of chronic obstructive pulmonary disease (COPD), etc. However, there is not enough evidence to support the systematic use of heliox to treat severe stages or acute exacerbations of COPD in either ventilated or non ventilated patients because there is currently no convincing impact on patient outcome. Therefore, at present, widespread use of heliox cannot be recommended in clinical practice.

Keywords: COPD; expiratory flow limitation; exercise; mechanical ventilation; non-invasive ventilation; helium-oxygen gas mixtures

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339809788922379

Publication date: 2009-08-01

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Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.