Simultaneous Characterization of Aerodynamic Size and Electrostatic Charge Distributions of Inhaled Dry Powder Inhaler Aerosols

Authors: Ali, Mohammed; Reddy, Rama N.; Mazumder, Malay K.

Source: Current Respiratory Medicine Reviews, Volume 4, Number 1, February 2008 , pp. 2-5(4)

Publisher: Bentham Science Publishers

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Abstract:

Respiratory drug particles aerosolized from Dry powder inhalers (DPIs) may charge electrostatically. Influence of electrostatic charge and aerodynamic size distributions on the regional deposition of inhaled aerosols in the lung has been acknowledged by the investigators of aerosol medicine research. This in vitro investigation reports a novel method of simultaneous measurement of both electrostatic charge and aerodynamic diameter of the particle in real time. The drug aerosols were generated by three commercially available and often prescribed DPIs by means of inhalation as a bolus at the rate of 30 L/min for 8 s, and then characterized by a Single Particle Aerodynamic Relaxation Time analyzer. The results showed that particles were not only varied sizes but also carried positive, negative and zero electrostatic charges. Aerosols generated by all three DPIs exhibited net electropositively charged.

Keywords: DPI aerosol; laser doppler velocimetry; aerodynamic size; electrostatic charge

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339808783497819

Publication date: 2008-02-01

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Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.