Depression in Sleep Related Breathing Disorder

Authors: Subramanian, Shyam; Rose, Mary; Surani, Salim

Source: Current Respiratory Medicine Reviews, Volume 3, Number 4, November 2007 , pp. 282-285(4)

Publisher: Bentham Science Publishers

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Abstract:

Sleep deprivation and sleep disruption have long been associated with mood disorders, both as a cause as well as an effect. Sleep-disordered breathing results in significant and persistent sleep disruption, which in turn leads to significant neurocognitive deficits [1,2] and major depression [3-6]. Various pathophysiologic mechanisms may play a role in modulating mood changes in these patients. Treatment for sleep-disordered breathing often improves mood [4, 7], though the data may suggest a placebo response [8]. Patients with sleep-disordered breathing should be carefully screened for mood disorders, and patients with major depression should be screened for possible underlying sleep-disordered breathing.

Keywords: Depression in OSA; sleep and depression; OSA and mood disorder; OSA and sleep disruption

Document Type: Research article

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