Depression in Sleep Related Breathing Disorder

Authors: Subramanian, Shyam; Rose, Mary; Surani, Salim

Source: Current Respiratory Medicine Reviews, Volume 3, Number 4, November 2007 , pp. 282-285(4)

Publisher: Bentham Science Publishers

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Abstract:

Sleep deprivation and sleep disruption have long been associated with mood disorders, both as a cause as well as an effect. Sleep-disordered breathing results in significant and persistent sleep disruption, which in turn leads to significant neurocognitive deficits [1,2] and major depression [3-6]. Various pathophysiologic mechanisms may play a role in modulating mood changes in these patients. Treatment for sleep-disordered breathing often improves mood [4, 7], though the data may suggest a placebo response [8]. Patients with sleep-disordered breathing should be carefully screened for mood disorders, and patients with major depression should be screened for possible underlying sleep-disordered breathing.

Keywords: Depression in OSA; sleep and depression; OSA and mood disorder; OSA and sleep disruption

Document Type: Research article

Publication date: 2007-11-01

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Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.