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A Case of Fatal Community-Acquired Necrotizing Pneumonia Caused by Panton-Valentine Leukocidin Positive Methicillin-Sensitive Staphylococcus Aureus

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The expression of Panton-Valentine leukocidin (PVL) has been implicated as a virulence factor for communityacquired Staphylococcus aureus pneumonia with most reported cases involving methicillin-resistant strains. Here we describe a case of community-acquired, PVL-positive methicillin-sensitive Staphylococcus aureus (MSSA) sufficiently virulent to cause rapidly progressive necrotizing pneumonia, massive pulmonary hemorrhage, sepsis, and death in a patient without conventional risk factors (diabetes, advanced age). To our knowledge, this is the first case report of a fatal necrotizing pneumonia caused by PVL-positive MSSA in Los Angeles County.

Keywords: MSSA; PVL; community-acquired necrotizing pneumonia and massive hemoptysis

Document Type: Research Article


Affiliations: Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 37-131 CHS, 10833 Le Conte Avenue, Los Angeles, California 90095-1690, USA.

Publication date: February 1, 2007

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  • Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.

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