Physiological Insights Derived from Mathematical Models of Respiration

Author: Longobardo, Guy¹

Source: Current Respiratory Medicine Reviews, Volume 2, Number 4, November 2006 , pp. 397-403(7)

Publisher: Bentham Science Publishers

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Abstract:

The structure of several respiratory models are reviewed and the physiological foundations of salient features are explained. The models reviewed include an early model of Cheyne-Stokes breathing, the gas stores of the body following alterations in ventilation, sleep apnea considered as instability in the respiratory control system, a neurochemical model describing effects of neural drives on breathing in respiratory control of awake people, and inclusion in the neurochemical control system a respiratory pattern generator, as a potential source of apneas. Finally, current work is described to quantify obstructive apneas, and their interdependence with central apneas and the respiratory control system.

Keywords: Apnea; central apnea; Cheyne-Stokes breathing; control of breathing; hypercapnia; hypoxia; neural drives; obstructive apneas; periodic breathing; sleep apnea

Document Type: Research article

DOI: 10.2174/157339806778777249

Affiliations: 1: 15 Crow's Nest Road, Bronxville, NY 10708, USA.

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