Physiological Insights Derived from Mathematical Models of Respiration

Author: Longobardo, Guy

Source: Current Respiratory Medicine Reviews, Volume 2, Number 4, November 2006 , pp. 397-403(7)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $62.88 plus tax (Refund Policy)

Abstract:

The structure of several respiratory models are reviewed and the physiological foundations of salient features are explained. The models reviewed include an early model of Cheyne-Stokes breathing, the gas stores of the body following alterations in ventilation, sleep apnea considered as instability in the respiratory control system, a neurochemical model describing effects of neural drives on breathing in respiratory control of awake people, and inclusion in the neurochemical control system a respiratory pattern generator, as a potential source of apneas. Finally, current work is described to quantify obstructive apneas, and their interdependence with central apneas and the respiratory control system.

Keywords: Apnea; central apnea; Cheyne-Stokes breathing; control of breathing; hypercapnia; hypoxia; neural drives; obstructive apneas; periodic breathing; sleep apnea

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339806778777249

Affiliations: 1: 15 Crow's Nest Road, Bronxville, NY 10708, USA.

Publication date: 2006-11-01

More about this publication?

Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.