Possible Purinergic Mechanisms of Carotid Chemoreceptors Transmission at High Altitude

Authors: Lahiri, Sukhamay; Baby, Santhosh M.; Roy, Arijit

Source: Current Respiratory Medicine Reviews, Volume 2, Number 4, November 2006 , pp. 393-396(4)

Publisher: Bentham Science Publishers

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Abstract:

In the last three decades studies of respiration have embarked on a new phase eliciting exciting new areas of investigation. At this juncture we are happy to contribute a brief article honoring NS Cherniack.

During this transition period, features like oxygen sensing in the carotid body in the context of whole body has emerged. ATP has been proposed as a key mediator of peripheral chemosensory transduction at sea level. What role it can play at altitude acclimatization has not been discussed before. This brief review article raises some of the question looking for answers.

Keywords: ATP; carotid body; central chemotransduction; oxygen sensing; purinergic transmission

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339806778777221

Affiliations: 1: Department of Physiology, University of Pennsylvania School of Medicine, B-400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA.

Publication date: 2006-11-01

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Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.