Transforming Growth Factor- Peptide Signaling in Lung Development: Bronchopulmonary Dysplasia, Lung Fibrosis and Emphysema

Authors: Warburton, David; Shi, Wei; Kolb, Martin; Gauldie, Jack

Source: Current Respiratory Medicine Reviews, Volume 1, Number 3, November 2005 , pp. 325-329(5)

Publisher: Bentham Science Publishers

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Abstract:

Recent findings show that the TGF bgr

peptide superfamily signaling pathway is not only essential for both prenatal and postnatal lung morphogenesis, but also plays a key role in the pathobiology of bronchopulmonary dysplasia, lung fibrosis and emphysema. Exquisitely tight regulation of TGF bgr

bioavailabilty and function is mediated at all levels of signal transduction from the extracelluar space to the nucleus. While the potential for therapeutic manipulation of TGF bgr

function is great, the practical application to pulmonary medicine will be exigent because of the requirement for exact modulation of TGF bgr

bioactivity and signaling within a very narrow physiological range.

Keywords: Bronchopulmonary Dysplasia; PROTEASE/ANTIPROTEASE; Matrix Metalloproteinases; elastin; lung function

Document Type: Review article

DOI: http://dx.doi.org/10.2174/157339805774598018

Affiliations: 1: Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, USA.

Publication date: 2005-11-01

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Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.